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What is Alzheimer’s? | Types of Dementia |
Stages of Alzheimer’s
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Dementia
is a clinical syndrome of loss or
decline in memory and other cognitive
abilities.
It is caused by various diseases and
conditions that result in damaged brain
cells.
Alzheimer’s
disease is a type of dementia and
the most common cause of dementia.
To be classified as dementia, the
syndrome must meet the following
criteria:
1. It must include decline in memory
and in at least one of the following
cognitive
abilities:
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Ability to generate coherent
speech and understand spoken or
written language; |
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Ability to recognize or identify
objects, assuming intact sensory
function; |
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Ability to perform motor
activities, assuming intact
motor abilities, sensory
function
and comprehension of the
required task;
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Ability to think abstractly,
make sound judgments and carry
out complex tasks.
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2.
The decline in cognitive abilities must
be severe enough to interfere with daily
life.
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Alzheimer’s Disease
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Most common type of dementia;
accounts for 60 to 80 percent of cases. Difficulty
remembering names and recent events is often an
early clinical symptom; later symptoms include
impaired judgment, disorientation, confusion,
behavior changes and trouble speaking, swallowing
and walking. Hallmark abnormalities are deposits of
the protein fragment beta-amyloid (plaques) and
twisted strands of the protein tau (tangles).
Vascular Dementia –
also known as multi-infarct or post
stroke dementia or vascular cognitive impairment.
Considered the second most common type of dementia.
Impairment is caused by decreased blood flow to
parts of the brain, often due to a series of small
strokes that block arteries. Symptoms often overlap
with those of Alzheimer’s, although memory may not be
as seriously effected.
Mixed Dementia -
Characterized by the presence of the
hallmark abnormalities of Alzheimer’s and another
type of dementia, most commonly vascular dementia,
but also other types, such as dementia with Lewy
bodies, frontal-temporal dementia, alcohol-related dementia
and normal pressure hydrocephalus.
Dementia with Lewy
Bodies - Pattern of decline may be
similar to Alzheimer’s, including problems with
memory, judgment and behavior changes. Alertness and
severity of cognitive symptoms may fluctuate daily.
Visual hallucinations, muscle rigidity and tremors
are common. Hallmarks include Lewy bodies (abnormal
deposits of the protein
alpha-synuclein) that form inside nerve cells in the
brain.
Parkinson’s Disease -
Many people who have Parkinson’s disease develop
dementia in the later stages of the disease.
Frontal-Temporal
Dementia - Involves damage to brain
cells, especially in the front and side regions of
the brain. Typical symptoms include changes in
personality and behavior and difficulty with
language. No distinguishing microscopic abnormality
is linked to all cases. Pick’s disease,
characterized by “Pick’s bodies,” is one type of
frontal-temporal dementia.
Creutzfeldt-Jacob
Dementia - Rapidly fatal disorder
that impairs memory and coordination and causes
behavior changes. It is believed to be caused by
consumption of products from cattle infected by “mad
cow disease.” Caused by the misfolding of prion
protein throughout the brain.
Normal pressure
Hydrocephalus - Caused by the buildup
of fluid in the brain. Symptoms include difficulty
walking, memory loss and inability to control urine.
Can sometimes be corrected with surgical
installation of a shunt in the brain to
drain excess fluid.
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STAGE 1:
No impairment
(normal function)
Unimpaired individuals experience no memory problems
and none are evident
to a health care professional during a medical
interview.
STAGE 2: Very
mild cognitive decline
(may be normal age-related changes or earliest signs
of Alzheimer’s disease)
Individuals may feel as if they have memory lapses,
especially in forgetting familiar words
or names or the location of keys, eyeglasses or
other everyday objects. But these
problems are not evident during a medical
examination or apparent to friends, family or
co-workers.
STAGE 3: Mild
cognitive decline
(Early-stage Alzheimer’s can be diagnosed in some,
but not all, individuals with
these symptoms)
Friends, family or co-workers begin
to notice deficiencies. Problems with memory
or concentration may be measurable in clinical
testing or discernible during a detailed medical
interview.
STAGE 4:
Moderate cognitive decline
(Mild or early-stage Alzheimer’s disease)
At this stage, a careful medical interview detects
clear-cut deficiencies in recent memory, impaired
ability to perform challenging mental arithmetic or
complex tasks, and reduced memory of personal
history. May seem subdued, withdrawn or depressed,
especially in socially or mentally challenging
situations.
STAGE 5:
Moderately severe cognitive decline
(Moderate or mid-stage Alzheimer’s disease)
Major gaps in memory and deficits in cognitive
function emerge. Some assistance with
day-to-day activities is now required.
STAGE 6:
Severe cognitive decline
(Moderately severe or mid-stage Alzheimer’s disease)
Memory difficulties continue to worsen, significant
personality changes may emerge and
affected individuals need extensive help with
customary daily activities.
STAGE 7:
Very
severe cognitive decline
(Severe or late-stage Alzheimer’s disease)
This is the final stage of the disease when
individuals lose the ability to respond to their
environment, the ability to speak and, ultimately,
the ability to control movement.
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More detailed information on these topics is
available at
www.alz.org
Information adapted from: 2008 Alzheimer’s Disease
Facts
and Figures / 2008 Alzheimer’s Association |
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